Cardiology

ARTEMIS: A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

The purpose of this study is to test how well a new medication can reduce the development of heart disease in patients who have come to the hospital with a heart attack. If the medication can reduce the development of heart disease this may prevent future heart attacks or strokes in these people.

Bariatric Surgery for the Reduction of CArdioVascular Events Randomized Controlled Trial

Obesity is common in people with heart disease and increases the risk of complications. The BRAVE study aims to determine if weight-loss (metabolic) surgery can safely reduce these risks in individuals with obesity and high-risk heart disease. Sub-studies will also assess the effects of bariatric surgery on quality of life, mental health, and healthcare costs.

COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events

Patients with multivessel disease undergo an angiogram to assess heart function, as blockages in multiple vessels increase the risk of oxygen deficiency and heart attack.

Fractional Flow Reserve (FFR), the current standard of care, helps cardiologists decide which blockages need stents. This study aims to determine whether using FFR alone or with Optical Coherence Tomography (OCT) better predicts future heart issues, such as heart attacks or cardiac-related death.

A randomized trial of physiology-guided versus angiography-guided nonculprit lesion (NCL) complete revascularization strategies

This trial also includes a prospective, observational, multi-centre, optical coherence tomography (OCT) imaging sub-study of patients with acute myocardial infarction and multi-vessel coronary artery disease.

This study includes heart attack patients who underwent Percutaneous Coronary Intervention (PCI) with stent placement and had at least one additional narrowed artery that was not the cause of the heart attack. While treating these additional blockages can reduce deaths and repeat heart attacks, some may not require intervention. This research compares two standard methods—pressure measurement (physiology) and visual inspection (angiography)—to determine which is better for guiding treatment and improving patient safety.

Heart Attack Research Program – Imaging Study

Most heart attacks are caused by blocked arteries, but some patients have no severe blockage on an angiogram, making the cause unclear. In these cases, further tests may reveal a different issue, such as inflammation, infection, or another condition. This study will perform two additional tests on patients without severe blockages to better understand their heart event.

The Fourth Left Atrial Appendage Occlusion Study

Atrial fibrillation is a common condition where the heart’s upper chambers beat too fast and irregularly, reducing pumping efficiency. This can cause blood to pool in the left atrial appendage, increasing the risk of clot formation. If a clot enters the bloodstream, it can block arteries and cause a stroke. Atrial fibrillation raises stroke risk by 3–5 times.

The LAAOS-4 study aims to determine if closing the left atrial appendage with the WATCHMAN FLX™ or FLX PRO™ device, along with Oral Anticoagulant (OAC) medication, is more effective at preventing strokes and blood clots than OAC medication alone.

LIBREXIA-ACS: A Phase 3, Randomized, Double-Blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome (ACS)

After a heart attack, patients receive standard treatments, including anticoagulant and antiplatelet medications, to lower the risk of another event. However, about 1 in 5 will have a second heart attack within five years. This study aims to determine whether the study drug can reduce the risk of recurrent heart attacks, blood clots, or stroke without significantly increasing bleeding.

LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure

Patients with heart block often rely on pacemakers to regulate their heart’s electrical signals. However, those completely dependent on pacemakers may develop pacing-induced cardiomyopathy, a weakening of the heart muscle that can lead to heart failure. This study compares a novel pacemaker placement approach, left bundle branch pacing, to standard right ventricular pacing to assess the risk of pacing-induced cardiomyopathy and heart failure.

A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome

16 participants enrolled

A 2x2 factorial randomized controlled trial of CoLchicine and spironolactonE in patients with myocARdial infarction/SYNERGY Stent Registry – Organization to Assess Strategies for Ischemic Syndromes 9

40 participants enrolled

Higher vs. Lower Dose Heparin for PCI

486 participants enrolled

Assessing the Effect of Asundexian on Thrombotic Status, in Particular Endogenous Fibrinolysis, in Patients With Atrial Fibrillation

8 participants enrolled

Prevalence of Subclinical Atrial Fibrillation in High Risk Heart Failure Patients and the Temporal Connection with Hospital Readmission for Heart Failure

3 participants enrolled

Routine Ultrasound Guidance for Vascular Access for Cardiac Procedures: a Randomized Trial

44 participants enrolled