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Critical Care Research Program

The Critical Care Research Program was co-founded by Dr. Jennifer Tsang and Dr. Erick Duan in 2017 with one multicentre clinical trial (PROSPECT Trial) and one half-time Research Coordinator. Within 6 years, our program has grown to include a total of four Physician Co-Leads (Dr. Jennifer Tsang, Dr. Erick Duan, Dr. Han-Oh Chung and Dr. Natasha Ovtcharenko), one senior Research Coordinator (Lisa Patterson) and two Research Assistants (Diane Nielsen-Smith and Aarthy Ehaparaseelan). Since the inception of the Critical Care Research Program, 22 clinical trials/observational studies were completed and 1,845 patients were enrolled in total. The Critical Care Research Program conduct multicentre (Canadian and multinational) clinical trials/observational studies in the areas of COVID-19, sepsis, pneumonia, diabetes, acute respiratory distress syndrome, mechanical ventilation and translational biology. Currently, we are conducting 11 active clinical trials/observational studies and 3 new clinical trials underway.  

The Critical Care Research Program received Leading Practice Designation by Health Standards Organization in 2021 and was ranked third in Canada by the Canadian Clinical Research Network in patient enrollment in research studies. The Critical Care Research Program contributes to many practice changing and high impact research publications.

Publications

  1. Writing Committee for the REMAP-CAP Investigators, Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D , Arabi YM , Beane A , van Bentum-Puijk W , Bhimani Z , Bonten MJM , Bradbury CA , Brunkhorst FM , Burrell A , Buzgau A , Buxton M , Charles WN , Cove M , Detry MA , Estcourt LJ , Fagbodun EO , Fitzgerald M , Girard TD , Goligher EC , Goossens H , Haniffa R , Hills T , Horvat CM , Huang DT , Ichihara N , Lamontagne F , Marshall JC , McAuley DF , McGlothlin
    A , McGuinness SP , McVerry BJ , Neal MD , Nichol AD , Parke RL , Parker JC , Parry-Billings K , Peters SEC , Reyes LF , Rowan KM , Saito H , Santos MS , Saunders CT , Serpa-Neto A , Seymour CW , Shankar-Hari M , Stronach LM , Turgeon AF , Turner AM , van de Veerdonk FL , Zarychanski R , Green C , Lewis RJ , Angus DC , McArthur CJ , Berry S , Derde LPG , Gordon AC , Webb SA , Lawler PR. (2023). Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.JAMA. 329(1): 39-51
  2. Alhazzani W , Parhar KKS , Weatherald J , Al Duhailib Z , Alshahrani M , Al-Fares A , Buabbas S , Cherian SV , Munshi L , Fan E , Al-Hameed F , Chalabi J , Rahmatullah AA , Duan E , Tsang JLY , Lewis K , Lauzier F , Centofanti J , Rochwerg B , Culgin S , Nelson K , Abdukahil SA , Fiest KM , Stelfox HT , Tlayjeh H , Meade MO , Perri D , Solverson K , Niven DJ , Lim R , Møller MH , Belley-Cote E , Thabane L , Tamim H , Cook DJ , Arabi YM , COVI-PRONE Trial Investigators and the Saudi Critical Care Trials Group. (2022). Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial.JAMA. 327(21): 2104-2113.
  3. Lau VI , Fowler R , Pinto R , Tremblay A , Borgia S , Carrier FM , Cheng MP , Conly J , Costiniuk CT , Daley P , Duan E , Durand M , Fontela PS , Farjou G , Fralick M , Geagea A , Grant J , Keynan Y , Khwaja K , Lee N , Lee TC , Lim R , O'Neil CR , Papenburg J , Semret M , Silverman M , Sligl W , Somayaji R , Tan DHS , Tsang JLY , Weatherald J , Yansouni CP , Zarychanski R , Murthy S , E-CATCO authors, AMMI Clinical Research Network and Canadian Critical Care Trials Group. (2022). Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial.CMAJ open. 10(3): E807-E817.
  4. Salter B , DeBenedictis B , Spatafora L , Kapralik J , Luo C , Qiu S , Dawson L , Junek M , Pitre T, Jones A , Beauchamp M , Kruisselbrink R , Duong M , Costa AP , Tsang JL , Ho T. (2022). Hospitalised COVID-19 outcomes are predicted by hypoxaemia and pneumonia phenotype irrespective of the timing of their emergence.BMJ open. 12(12): e062453.
  5. REMAP-CAP Writing Committee for the REMAP-CAP Investigators , Bradbury CA , Lawler PR , Stanworth SJ , McVerry BJ , McQuilten Z , Higgins AM , Mouncey PR , Al-Beidh F , Rowan KM , Berry LR , Lorenzi E , Zarychanski R , Arabi YM , Annane D , Beane A , van Bentum-Puijk W , Bhimani Z , Bihari S , Bonten MJM , Brunkhorst FM , Buzgau A , Buxton M, Carrier M , Cheng AC , Cove M , Detry MA , Estcourt LJ , Fitzgerald M , Girard TD , Goligher EC , Goossens H , Haniffa R , Hills T , Huang DT , Horvat CM , Hunt BJ , Ichihara N , Lamontagne F , Leavis HL , Linstrum KM , Litton E , Marshall JC , McAuley DF , McGlothlin A , McGuinness SP , Middeldorp S , Montgomery SK , Morpeth SC , Murthy S , Neal MD , Nichol AD , Parke RL , Parker JC , Reyes LF , Saito H , Santos MS , Saunders CT , Serpa-Neto A , Seymour CW , Shankar-Hari M , Singh V , Tolppa T , Turgeon AF , Turner AM , van de Veerdonk FL , Green C , Lewis RJ , Angus DC , McArthur CJ , Berry S , Derde LPG , Webb SA , Gordon AC. (2022). Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.JAMA. 327(13): 1247-1259.
  6. Reid JC , Molloy A , Strong G , Kelly L , O'Grady H , Cook D , Archambault PM , Ball I , Berney S , Burns KEA , D'Aragon F , Duan E , English SW , Lamontagne F , Pastva AM , Rochwerg B , Seely AJE , Serri K , Tsang JLY , Verceles AC , Reeve B , Fox-Robichaud A , Muscedere J , Herridge M , Thabane L , Kho ME , CYCLE Investigators. (2022). Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic.Trials. 23(1): 735.
  7. Ali K , Azher T , Baqi M , Binnie A , Borgia S , Carrier FM , Cavayas YA , Chagnon N , Cheng MP , Conly J , Costiniuk C , Daley P , Daneman N , Douglas J , Downey C , Duan E , Duceppe E , Durand M , English S , Farjou G , Fera E , Fontela P , Fowler R , Fralick M , Geagea A , Grant J , Harrison LB , Havey T , Hoang H , Kelly LE , Keynan Y , Khwaja K , Klein G , Klein M , Kolan C , Kronfli N , Lamontagne F , Lau R , Fralick M , Lee TC , Lee N , Lim R , Longo S , Lostun A , MacIntyre E , Malhamé I , Mangof K , McGuinty M , Mergler S , Munan MP , Murthy S , O'Neil C , Ovakim D , Papenburg J , Parhar K , Parvathy SN , Patel C , Perez-Patrigeon S , Pinto R , Rajakumaran S , Rishu A , Roba-Oshin M , Rushton M , Saleem M , Salvadori M , Scherr K , Schwartz K , Semret M , Silverman M , Singh A , Sligl W , Smith S , Somayaji R, Tan DHS , Tobin S , Todd M , Tran TV , Tremblay A , Tsang J , Turgeon A , Vakil E , Weatherald J , Yansouni C , Zarychanski R , Canadian Treatments for COVID-19 (CATCO). (2022). Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. NA: NA.
  8. Dionne JC , Mbuagbaw L , Devlin JW , Duprey MS , Cartin-Ceba R , Tsang J , Sullivan K , Muscedere J , Alshahrani M , Szczeklik W , Lysecki P , Takaoka A , Reeve B , Campbell T , Borowska K , Serednicki W , Cirone R , Alhazzani W , Moayyedi P , Armstrong D , Thabane L , Jaeschke R , Hamielec C , Karachi T , Cook DJ , DICE Investigators. (2022). Diarrhea during critical illness: a multicenter cohort study.Intensive care medicine. 48(5): 570-579.
  9. REMAP-CAP Investigators , Gordon AC , Mouncey PR , Al-Beidh F , Rowan KM , Nichol AD, Arabi YM , Annane D , Beane A , van Bentum-Puijk W , Berry LR , Bhimani Z , Bonten MJM , Bradbury CA , Brunkhorst FM , Buzgau A , Cheng AC , Detry MA , Duffy EJ , Estcourt LJ , Fitzgerald M , Goossens H , Haniffa R , Higgins AM , Hills TE , Horvat CM , Lamontagne F , Lawler PR , Leavis HL , Linstrum KM , Litton E , Lorenzi E , Marshall JC , Mayr FB , McAuley DF , McGlothlin A , McGuinness SP , McVerry BJ , Montgomery SK , Morpeth SC , Murthy S , Orr K , Parke RL , Parker JC , Patanwala AE , Pettilä V , Rademaker E , Santos MS , Saunders CT , Seymour CW , Shankar-Hari M , Sligl WI , Turgeon AF , Turner AM , van de Veerdonk FL , Zarychanski R , Green C , Lewis RJ , Angus DC , McArthur CJ , Berry S , Webb SA , Derde LPG. (2021). Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.The New England journal of medicine. 384(16): 1491-1502.
  10. Pitre, T., Jones, A., Su, J., Helmeczi, W., Xu, G., Lee, C., Shamsuddin, A., Mir, A., MacGregor, S., Duong, M., Ho, T., Beauchamp, MK., Costa, A.P., Kruisselbrink, R, on behalf of the COREG Investigators. (2021). Inflammatory Biomarkers as Independent Prognosticators of 28-Day Mortality for COVID-19 Patients Admitted to General Medicine or ICU Wards: A Retrospective Cohort Study. Internal and Emergency Medicine.
  11. REMAP-CAP Investigators , ACTIV-4a Investigators , ATTACC Investigators , Goligher EC , Bradbury CA , McVerry BJ , Lawler PR , Berger JS , Gong MN , Carrier M , Reynolds HR , Kumar A , Turgeon AF , Kornblith LZ , Kahn SR , Marshall JC , Kim KS , Houston BL , Derde LPG , Cushman M , Tritschler T , Angus DC , Godoy LC , McQuilten Z , Kirwan BA , Farkouh ME , Brooks MM , Lewis RJ , Berry LR , Lorenzi E , Gordon AC , Ahuja T , Al-Beidh F , Annane D , Arabi YM , Aryal D , Baumann Kreuziger L , Beane A , Bhimani Z , Bihari S , Billett HH , Bond L , Bonten M , Brunkhorst F , Buxton M , Buzgau A , Castellucci LA , Chekuri S , Chen JT , Cheng AC , Chkhikvadze T , Coiffard B , Contreras A , Costantini TW, de Brouwer S , Detry MA , Duggal A , Džavík V , Effron MB , Eng HF , Escobedo J , Estcourt LJ , Everett BM , Fergusson DA , Fitzgerald M , Fowler RA , Froess JD , Fu Z , Galanaud JP, Galen BT , Gandotra S , Girard TD , Goodman AL , Goossens H , Green C , Greenstein YY , Gross PL , Haniffa R ,. (2021). Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. The New England journal of medicine. 385(9): 777-789.
  12. Johnstone J , Meade M , Lauzier F , Marshall J , Duan E , Dionne J , Arabi YM , Heels-Ansdell D , Thabane L , Lamarche D , Surette M , Zytaruk N , Mehta S , Dodek P , McIntyre L , English S , Rochwerg B , Karachi T , Henderson W , Wood G , Ovakim D , Herridge M , Granton J , Wilcox ME , Goffi A , Stelfox HT , Niven D , Muscedere J , Lamontagne F , D'Aragon F , St-Arnaud C , Ball I , Nagpal D , Girard M , Aslanian P , Charbonney E , Williamson D , Sligl W , Friedrich J , Adhikari NK , Marquis F , Archambault P , Khwaja K , Kristof A , Kutsogiannis J , Zarychanski R , Paunovic B , Reeve B , Lellouche F , Hosek P , Tsang J , Binnie A , Trop S , Loubani O , Hall R , Cirone R , Reynolds S , Lysecki P , Golan E , Cartin-Ceba R , Taylor R , Cook D , Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. (2021). Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.JAMA. 326(11): 1024-1033.
  13. Pitre T , Dong AHT , Jones A , Kapralik J , Cui S , Mah J , Helmeczi W , Su J , Patel V , Zia Z , Mallender M , Tang X , Webb C , Patro N , Junek M , Duong M , Ho T , Beauchamp MK , Costa AP , Kruisselbrink R , Tsang JLY , Walsh M. (2021). Incidence and Outcomes of Acute Kidney Injury in Patients Admitted to Hospital With COVID-19: A Retrospective Cohort Study. Canadian journal of kidney health and disease. 8: 20543581211027759.
  14. ATTACC Investigators , ACTIV-4a Investigators , REMAP-CAP Investigators , Lawler PR , Goligher EC , Berger JS , Neal MD , McVerry BJ , Nicolau JC , Gong MN , Carrier M , Rosenson RS , Reynolds HR , Turgeon AF , Escobedo J , Huang DT , Bradbury CA , Houston BL , Kornblith LZ , Kumar A , Kahn SR , Cushman M , McQuilten Z , Slutsky AS , Kim KS , Gordon AC , Kirwan BA , Brooks MM , Higgins AM , Lewis RJ , Lorenzi E , Berry SM , Berry LR , Aday AW , Al-Beidh F , Annane D , Arabi YM , Aryal D , Baumann Kreuziger L , Beane A , Bhimani Z , Bihari S , Billett HH , Bond L , Bonten M , Brunkhorst F , Buxton M , Buzgau A , Castellucci LA , Chekuri S , Chen JT , Cheng AC , Chkhikvadze T , Coiffard B , Costantini TW , de Brouwer S , Derde LPG , Detry MA , Duggal A , Džavík V , Effron MB , Estcourt LJ , Everett BM , Fergusson DA , Fitzgerald M , Fowler RA , Galanaud JP , Galen BT , Gandotra S , García- Madrona S , Girard TD , Godoy LC , Goodman AL , Goossens H , Green C , Greenstein YY , Gross PL , Ha. (2021). Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.The New England journal of medicine. 385(9): 790-802.
  15. Jones A , Pitre T , Junek M , Kapralik J , Patel R , Feng E , Dawson L , Tsang JLY , Duong M , Ho T , Beauchamp MK , Costa AP , Kruisselbrink R , COREG Investigators. (2021). External validation of the 4C mortality score among COVID-19 patients admitted to hospital in Ontario, Canada: a retrospective study.Scientific reports. 11(1): 18638.
  16. Murthy S , Archambault PM , Atique A , Carrier FM , Cheng MP , Codan C , Daneman N , Dechert W , Douglas S , Fiest KM , Fowler R , Goco G , Gu Y , Guerguerian AM , Hall R , Hsu JM , Joffe A , Jouvet P , Kelly L , Kho ME , Kruisselbrink RJ , Kumar D , Kutsogiannis DJ , Lamontagne F , Lee TC , Menon K , O'Grady H , O'Hearn K , Ovakim DH , Pharand SG , Pitre T , Reel R , Reeve B , Rewa O , Richardson D , Rishu A , Sandhu G , Sarfo-Mensah S , Shadowitz E , Sligl W , Solomon J , Stelfox HT , Swanson A , Tessier-Grenier H , Tsang JLY , Wood G , SPRINT-SARI Canada Investigators and the Canadian Critical Care Trials Group. (2021-01-01). Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study.CMAJ open. 9(1): E181-E188.
  17. Arabi YM , Gordon AC , Derde LPG , Nichol AD , Murthy S , Beidh FA , Annane D , Swaidan LA , Beane A , Beasley R , Berry LR , Bhimani Z , Bonten MJM , Bradbury CA , Brunkhorst FM , Buxton M , Buzgau A , Cheng A , De Jong M , Detry MA , Duffy EJ , Estcourt LJ , Fitzgerald M , Fowler R , Girard TD , Goligher EC , Goossens H , Haniffa R , Higgins AM , Hills TE , Horvat CM , Huang DT , King AJ , Lamontagne F , Lawler PR , Lewis R , Linstrum K , Litton E , Lorenzi E , Malakouti S , McAuley DF , McGlothlin A , Mcguinness S , McVerry BJ , Montgomery SK , Morpeth SC , Mouncey PR , Orr K , Parke R , Parker JC , Patanwala AE , Rowan KM , Santos MS , Saunders CT , Seymour CW , Shankar-Hari M , Tong SYC , Turgeon AF , Turner AM , Van de Veerdonk FL , Zarychanski R , Green C , Berry S , Marshall JC , McArthur C , Angus DC , Webb SA , REMAP-CAP Investigators. (2021). Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial.Intensive care medicine. 47(8): 867-886.
  18. WHO Solidarity Trial Consortium , Pan H , Peto R , Henao-Restrepo AM , Preziosi MP , Sathiyamoorthy V , Abdool Karim Q , Alejandria MM , Hernández García C , Kieny MP , Malekzadeh R , Murthy S , Reddy KS , Roses Periago M , Abi Hanna P , Ader F , Al-Bader AM , Alhasawi A , Allum E , Alotaibi A , Alvarez- Moreno CA , Appadoo S , Asiri A , Aukrust P , Barratt-Due A , Bellani S , Branca M , Cappel-Porter HBC , Cerrato N , Chow TS , Como N , Eustace J , García PJ , Godbole S , Gotuzzo E , Griskevicius L , Hamra R , Hassan M , Hassany M , Hutton D , Irmansyah I , Jancoriene L , Kirwan J , Kumar S , Lennon P , Lopardo G , Lydon P , Magrini N , Maguire T , Manevska S , Manuel O , McGinty S , Medina MT , Mesa Rubio ML , Miranda-Montoya MC , Nel J , Nunes EP , Perola M , Portolés A , Rasmin MR , Raza A , Rees H , Reges PPS , Rogers CA , Salami K , Salvadori MI , Sinani N , Sterne JAC , Stevanovikj M , Tacconelli E , Tikkinen KAO , Trelle S , Zaid H , Røttingen JA , Swaminathan S. (2021). Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.The New England journal of medicine. 384(6): 497-511.
  19. Writing Committee for the REMAP-CAP Investigators , Estcourt LJ , Turgeon AF , McQuilten ZK , McVerry BJ , Al-Beidh F , Annane D , Arabi YM , Arnold DM , Beane A , Bégin P , van Bentum-Puijk W , Berry LR , Bhimani Z , Birchall JE , Bonten MJM , Bradbury CA , Brunkhorst FM , Buxton M , Callum JL , Chassé
    M , Cheng AC , Cove ME , Daly J , Derde L , Detry MA , De Jong M , Evans A , Fergusson DA , Fish M , Fitzgerald M , Foley C , Goossens H , Gordon AC , Gosbell IB , Green C , Haniffa R , Harvala H , Higgins AM , Hills TE , Hoad VC , Horvat C , Huang DT , Hudson CL , Ichihara N , Laing E , Lamikanra
    AA , Lamontagne F , Lawler PR , Linstrum K , Litton E , Lorenzi E , MacLennan S , Marshall J , McAuley DF , McDyer JF , McGlothlin A , McGuinness S , Miflin G , Montgomery S , Mouncey PR , Murthy S , Nichol A , Parke R , Parker JC , Priddee N , Purcell DFJ , Reyes LF , Richardson P , Robitaille N , Rowan KM , Rynne J , Saito H , Santos M , Saunders CT , Serpa Neto A , Seymour CW , Silversides . (2021). Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.JAMA. 326(17): 1690-1702.
  20. Bégin P , Callum J , Jamula E , Cook R , Heddle NM , Tinmouth A , Zeller MP , Beaudoin-Bussières
    G , Amorim L , Bazin R , Loftsgard KC , Carl R , Chassé M , Cushing MM , Daneman N , Devine DV , Dumaresq J , Fergusson DA , Gabe C , Glesby MJ , Li N , Liu Y , McGeer A , Robitaille N , Sachais BS , Scales DC , Schwartz L , Shehata N , Turgeon AF , Wood H , Zarychanski R , Finzi A , CONCOR-1 Study Group , Arnold DM. (2021). Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.Nature medicine. 27(11): 2012-2024.
  21. Angus DC , Derde L , Al-Beidh F , Annane D , Arabi Y , Beane A , van Bentum-Puijk W , Berry L , Bhimani Z , Bonten M , Bradbury C , Brunkhorst F , Buxton M , Buzgau A , Cheng AC , de Jong M , Detry M , Estcourt L , Fitzgerald M , Goossens H , Green C , Haniffa R , Higgins AM , Horvat C , Hullegie SJ , Kruger P , Lamontagne F , Lawler PR , Linstrum K , Litton E , Lorenzi E , Marshall J , McAuley D , McGlothin A , McGuinness S , McVerry B , Montgomery S , Mouncey P , Murthy S , Nichol A , Parke R , Parker J , Rowan K , Sanil A , Santos M , Saunders C , Seymour C , Turner A , van de Veerdonk F , Venkatesh
    B , Zarychanski R , Berry S , Lewis RJ , McArthur C , Webb SA , Gordon AC , Writing Committee for the REMAP-CAP Investigators , Al-Beidh F , Angus D , Annane D , Arabi Y , van Bentum-Puijk W , Berry S , Beane A , Bhimani Z , Bonten M , Bradbury C , Brunkhorst F , Buxton M , Cheng A , De Jong M , Derde L , Estcourt L , Goossens H , Gordon A , Green C , Haniffa R , Lamontagne F , Lawler P . (2020). Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.JAMA. 324(13): 1317-1329.
  22. Lau, V.I., Cook ,D.J., Fowler, R., Rochwerg, B., Johnstone, J., Lauzier, F., Marshall J.C., Basmaji, J., Heels-Ansdell D., Thabane, L., Xie, F., PROSPECT Collaborators. (2020). Economic Evaluation Alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): Study Protocol. British Medical Journal Open.

Critical Care Research Team

Dr. Jennifer Tsang
Physician Co-Lead

Dr. Erick Duan
Physician Co-Lead

Dr. Han-Oh Chung
Physician Co-Lead

Dr. Natasha Ovtcharenko
Physician Co-Lead

Lisa Patterson,
Senior Research Coordinator

Diane Nielsen-Smith,
Research Assistant

Aarthy Ehaparaseelan,
Research Assistant

Niagara Health System